Affiliation:
1. Department of Biology University of Fribourg Fribourg Switzerland
2. Université Côte d'Azur, Inserm, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire Valbonne France
3. Swiss National Center for Competence in Research (NCCR) Bio‐inspired Materials University of Fribourg Fribourg Switzerland
Abstract
Lipid droplets (LDs) are ubiquitous intracellular organelles with a central role in multiple lipid metabolic pathways. However, identifying correlations between their structural properties and their biological activity has proved challenging, owing to their unique physicochemical properties as compared with other cellular membranes. In recent years, molecular dynamics (MD) simulations, a computational methodology allowing the accurate description of molecular assemblies down to their individual components, have been demonstrated to be a useful and powerful approach for studying LD structural and dynamical properties. In this short review, we attempt to highlight, as comprehensively as possible, how MD simulations have contributed to our current understanding of multiple molecular mechanisms involved in LD biology.
Funder
H2020 European Research Council
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Cited by
2 articles.
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