Prospective Design of Anti‐Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain-Reference-Cited by-同舟云学术

Prospective Design of Anti‐Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain

Published:2016-05 Issue:5 Volume:5 Page:283-291
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Kanodia JS¹,Gadkar K¹,Bumbaca D¹,Zhang Y²,Tong RK³,Luk W⁴,Hoyte K⁴,Lu Y⁴,Wildsmith KR⁵,Couch JA⁶,Watts RJ⁷,Dennis MS²,Ernst JA³,Scearce‐Levie K⁷,Atwal JK⁷,Ramanujan S¹,Joseph S¹

Affiliation:

1. Preclinical and Translational Pharmacokinetics DepartmentGenentechSouth San Francisco California USA

2. Antibody Engineering DepartmentGenentechSouth San Francisco California USA

3. Protein Sciences, GenentechSouth San Francisco California USA

4. Biochemical and Cellular PharmacologyGenentechSouth San Francisco California USA

5. Biomarker Development, GenentechSouth San Francisco California USA

6. Safety Assessment, GenentechSouth San Francisco California USA

7. Department of NeuroscienceGenentechSouth San Francisco California USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12081

Reference28 articles.

1. Targeted delivery of protein and gene medicines through the blood-brain barrier

2. Macromolecular permeability across the blood-nerve and blood-brain barriers.

3. Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

4. Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases

5. Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.

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