Pharmacokinetics of Anti‐VEGF Agent Aflibercept in Cancer Predicted by Data‐Driven, Molecular‐Detailed Model-Reference-Cited by-同舟云学术

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Pharmacokinetics of Anti‐VEGF Agent Aflibercept in Cancer Predicted by Data‐Driven, Molecular‐Detailed Model

Published:2015-10-09 Issue:11 Volume:4 Page:641-649
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Finley SD¹,Angelikopoulos P²,Koumoutsakos P²,Popel AS³

Affiliation:

1. Department of Biomedical EngineeringUniversity of Southern CaliforniaLos Angeles California USA

2. Computational Science and Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich Switzerland

3. Department of Biomedical EngineeringJohns Hopkins University School of MedicineBaltimore Maryland USA

Funder

National Institutes of Health

European Research Council

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12040

Reference24 articles.

1. VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade

2. The Pharmacokinetic/Pharmacodynamic Pipeline: Translating Anticancer Drug Pharmacology to the Clinic

3. Pharmacokinetic/ Pharmacodynamic-Driven Drug Development

4. Development of Translational Pharmacokinetic–Pharmacodynamic Models

5. Multiscale Mechanistic Modeling in Pharmaceutical Research and Development

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