Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective-Reference-Cited by-同舟云学术

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Published:2018-10-22 Issue:5 Volume:104 Page:916-932
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Kenna J. Gerry¹,Taskar Kunal S.²,Battista Christina³,Bourdet David L.⁴,Brouwer Kim L.R.⁵,Brouwer Kenneth R.⁶,Dai David⁷,Funk Christoph⁸,Hafey Michael J.⁹,Lai Yurong¹⁰,Maher Jonathan¹¹,Pak Y. Anne¹²,Pedersen Jenny M.¹³,Polli Joseph W.¹⁴,Rodrigues A. David¹⁵,Watkins Paul B.¹⁶,Yang Kyunghee³,Yucha Robert W.¹⁷,

Affiliation:

1. Safer Medicines Trust; Kingsbridge UK

2. Mechanistic Safety and Disposition; IVIVT; GlaxoSmithKline; Ware Hertfordshire UK

3. DILIsym Services Inc., a Simulations Plus Company; Research Triangle Park North Carolina USA

4. Drug Metabolism and Pharmacokinetics; Theravance Biopharma; South San Francisco California USA

5. Division of Pharmacotherapy and Experimental Therapeutics; UNC Eshelman School of Pharmacy; University of North Carolina at Chapel Hill; Chapel Hill North Carolina USA

6. ADME-TOX; BioIVT; Durham North Carolina USA

7. Clinical Pharmacology; Research and Development Sciences; Agios Pharmaceuticals; Cambridge Massachusetts USA

8. Roche Pharmaceutical Research and Early Development; Pharmaceutical Sciences; Roche Innovation Center Basel; Basel Switzerland

9. Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism; Merck & Co., Inc; Kenilworth New Jersey USA

10. Drug Metabolism; Gilead Sciences Inc.; Foster City California USA

11. Safety Assessment; Genentech; South San Francisco California USA

12. Lilly Research Laboratory; Lilly Corporate Center; Eli Lilly and Company; Indianapolis Indiana USA

13. Department of Neurobiology, Care Sciences and Society; Karolinska Institute; Novum Huddinge Sweden

14. Mechanistic Safety and Drug Disposition; GlaxoSmithKline; King of Prussia Pennsylvania USA

15. PDM; Medicine Design; Pfizer Inc.; Groton Connecticut USA

16. Institute for Drug Safety Sciences; UNC Eshelman School of Pharmacy; University of North Carolina; Chapel Hill North Carolina USA

17. Takeda Pharmaceuticals, Global Drug Metabolism and Pharmacokinetics; Cambridge Massachusetts USA

Funder

National Institute of General Medical Sciences

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cpt.1222/fullpdf

Reference110 articles.

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2. Bile acid metabolism and signaling in liver disease and therapy;Chiang;Liver Res.,2017

3. The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease;Lam;Semin. Liver Dis.,2010

4. Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability;Ho;Pharmacogenet. Genomics,2010

5. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis;Strautnieks;Nat. Genet.,1998

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