Affiliation:
1. School of Marine Science and Technology Harbin Institute of Technology at Weihai Weihai Shandong 264209 China
2. State Key Laboratory of Urban Water Resource and Environment Harbin Institute of Technology Harbin China
3. School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin China
Abstract
RationaleMicrodroplet chemistry has attracted tremendous interest in recent years. We have previously reported that microdroplet mass spectrometry (MS) achieves reaction acceleration. Here we systematically investigated the effect of capillary heating of MS inlet and solvent polarity of microdroplets on the conversion ratios of dehydration and phosphorylation reactions.MethodsThe micron‐sized droplets generated by high‐speed gas encapsulated the compounds. The conversion ratios of dehydration and phosphorylation reactions were investigated at different capillary temperatures of MS inlet between 30°C and 300°C. Subsequently, the effects of solvent polarity of different microdroplets (acetonitrile, acetonitrile/water [v/v: 9:1], and water) on microdroplet reactions were investigated.ResultsThe microdroplets could be used as reaction vessels for rapid dehydration and phosphorylation reactions. Microdroplet MS is characterized by the completion of the reaction in microseconds. The increase in capillary temperature increased the conversion ratio of dehydration reactions but had little effect on phosphorylation reactions. The stability of compounds supports this phenomenon. In addition, the increase in solvent polarity in microdroplets promoted the dehydration reaction but inhibited the nucleophilic substitution reaction (phosphorylation reaction).ConclusionsMicrodroplet MS achieved an acceleration of the reaction, which was attributed to capillary temperature, microdroplet solvents, and the stability of reaction products. This finding suggested that the inlet capillary and solvent system should be considered in the study and interpretation of microdroplet MS.
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Spectroscopy,Analytical Chemistry