Quality of life following surgery for head and neck cancer: Evidence from <scp>ACRIN</scp> 6685-Reference-Cited by-同舟云学术

Quality of life following surgery for head and neck cancer: Evidence from ACRIN 6685

Published:2024-02-14 Issue:8 Volume:46 Page:1988-1998
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Hollenbeak Christopher S.¹^ORCID,Duan Fenghai²,Subramaniam Rathan M.³⁴⁵,Taurone Alexander²,Sicks JoRean²,Lowe Val J.⁶,Stack Brendan C.⁷

Affiliation:

1. Department of Health Policy and Administration College of Health and Human Development, The Pennsylvania State University University Park Pennsylvania USA

2. Department of Biostatistics and Center for Statistical Sciences Brown University School of Public Health Providence Rhode Island USA

3. Faculty of Medicine, Nursing, Midwifery and Health Sciences University of Notre Dame Australia Sydney Australia

4. Department of Radiology Duke University Durham North Carolina USA

5. Department of Medicine University of Otago Medical School Dunedin New Zealand

6. Department of Radiology Mayo Clinic Rochester Minnesota USA

7. Department of Otolaryngology – Head Neck Surgery Southern Illinois University School of Medicine Springfield Illinois USA

Abstract

AbstractBackgroundThis study examined the trajectory of health‐related quality of life (HRQoL) for patients with clinical stage N0 HNSCC enrolled in ACRIN 6685 who underwent elective neck dissection(s).MethodsHRQoL of 230 patients in the ACRIN 6685 trial was measured prospectively up to 2 years following surgery using the University of Washington Quality of Life instrument.ResultsGeneral Health Within the Last 7 Days did not differ significantly from baseline at any follow‐up. General Health Relative to Before Cancer fell significantly by 5.8 points following surgery (p = 0.048), and then returned to 3.0 points above baseline at 1 year (p = 0.65). For Overall Quality of Life, HRQoL fell significantly by 4.3 points following surgery (p = 0.031) and then returned to levels not significantly different from baseline.ConclusionsPatients with stage N0 HNSCC experience significant declines in HRQoL immediately following surgery, including neck dissection, which recovers to near or better than baseline within 1–2 years.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27673

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