ddX: Polarizable continuum solvation from small molecules to proteins

Author:

Nottoli Michele1ORCID,Herbst Michael F.2ORCID,Mikhalev Aleksandr3,Jha Abhinav1,Lipparini Filippo4ORCID,Stamm Benjamin1ORCID

Affiliation:

1. Universität Stuttgart Institute of Applied Analysis and Numerical Simulation Stuttgart Germany

2. Mathematics for Materials Modelling Institute of Mathematics & Institute of Materials, École Polytechnique Fédérale de Lausanne Lausanne Switzerland

3. Center for Artificial Intelligence Technology Skolkovo Institute of Science and Technology Moscow Russia

4. Dipartimento di Chimica e Chimica Industriale Universitá di Pisa Pisa Italy

Abstract

AbstractPolarizable continuum solvation models are popular in both, quantum chemistry and in biophysics, though typically with different requirements for the numerical methods. However, the recent trend of multiscale modeling can be expected to blur field‐specific differences. In this regard, numerical methods based on domain decomposition (dd) have been demonstrated to be sufficiently flexible to be applied all across these levels of theory while remaining systematically accurate and efficient. In this contribution, we present ddX, an open‐source implementation of dd‐methods for various solvation models, which features a uniform interface with classical as well as quantum descriptions of the solute, or any hybrid versions thereof. We explain the key concepts of the library design and its application program interface, and demonstrate the use of ddX for integrating into standard chemistry packages. Numerical tests illustrate the performance of ddX and its interfaces.This article is categorized under: Software > Quantum Chemistry Software > Simulation Methods

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

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