Human regulatory T cells are selectively activated by low‐dose application of the CD28 superagonist TGN1412/TAB08
Author:
Affiliation:
1. Institute for Virology and Immunobiology University of Würzburg Würzburg Germany
2. TheraMAB LLC Würzburg Germany
3. TheraMAB LLC Moscow Russian Federation
4. Department of Internal Medicine II University Hospital of Würzburg Würzburg Germany
Funder
Deutsche Forschungsgemeinschaft
TheraMab LLC
Publisher
Wiley
Subject
Immunology,Immunology and Allergy
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.201343967
Reference46 articles.
1. CD28-mediated induction of proliferation in resting T cellsin vitro andin vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28
2. CD28-Mediated Activation of Resting Human T Cells without Costimulation of the CD3/TCR Complex
3. Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis
4. Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice
5. Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist
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