Poly (glycerol sebacate) – co – 2 – hydroxyethyl methacrylate bioelastomeric nanohydroxyapatite composites: Mechanical properties, thermal characteristics, and cytocompatibility studies

Abstract

AbstractIn this study bioelastomeric co‐polymer comprised of glycerol, sebacic acid, and 2‐hydroxyethyl methacrylate, loaded with varied contents of nanohydroxyapatite (0%–8%) has been synthesized via polycondensation reaction. The mechanical properties, that is, tensile and compressive strength and modulus have been enhanced due to the addition of silane‐treated nanohydroxyapatite. The optimal mechanical properties for these nanocomposites have been found to be at 7% nanohydroxyapatite loading. X‐Ray diffraction analysis and scanning electron microscopy (SEM) revealed efficient dispersion of nanohydroxyapatite throughout the matrix as particles and as well as agglomerates. The synthesized composite was found to be cytocompatible and showed excellent biocompatibility by forming thick apatite layers in simulated body fluid.Highlights Synthesis of PGS/nHA bioelastomeric nanocomposite via polycondensation. Characterization of nanocomposite with FTIR, TGA, XRD, SEM, AFM. Water absorption, bioactivity and cytocompatibility assessment. In vitro degradation evaluation.