Periodontal disease and risk of Alzheimer's disease: A two‐sample Mendelian randomization-Reference-Cited by-同舟云学术

Periodontal disease and risk of Alzheimer's disease: A two‐sample Mendelian randomization

Published:2024-04 Issue:4 Volume:14 Page:
ISSN:2162-3279
Container-title:Brain and Behavior
language:en
Short-container-title:Brain and Behavior

Author:

Hu Conglei¹^ORCID,Li Hui²,Huang Liping³⁴,Wang Rui⁵⁶,Wang Zeyu¹,Ma Rui¹,Chang Bei⁷,Li Shiting³⁴,Li Hongcai⁸,Li Guangwen³⁴⁶

Affiliation:

1. Graduate School Air Force Medical University Xi'an China

2. Department of Epidemiology and Statistics School of Public Health, Southwest Medical University Luzhou China

3. Department of Oral Implantology The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration Luzhou China

4. Institute of Stomatology Southwest Medical University Luzhou China

5. Department of Medical Education Tangdu Hospital, Air Force Medical University Xi'an China

6. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases School of Stomatology, Air Force Medical University Xi'an China

7. Department of Stomatology The PLA Rocket Force Characteristic Medical Center Beijing China

8. Department of Stomatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China

Abstract

AbstractBackgroundEvidence from observational studies and clinical trials suggests an association between periodontal disease and Alzheimer's disease (AD). However, the causal relationship between periodontal disease and AD remains to be determined.MethodsWe obtained periodontal disease data from the FinnGen database and two sets of AD data from the IEU consortium and PGC databases. Subsequently, we conducted a two‐sample Mendelian randomization (MR) analysis to investigate the causal relationship between periodontal disease and AD.ResultsThe results of the random‐effects IVW analysis revealed no evidence of a genetic causal relationship between periodontal disease and AD, regardless of whether the AD data from the IEU consortium or the AD data from the PGC database were utilized. No heterogeneity, multiple effects of levels, or outliers were observed in this study.ConclusionsOur findings indicate that there is no causal relationship between periodontal disease and AD at the genetic level.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/brb3.3486

Reference42 articles.

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