How do we make progress in phenotyping patients with lower urinary tract such as overactive bladder and underactive detrusor, including using urine markers and microbiome data, to personalize therapy? ICI‐RS 2023

How do we make progress in phenotyping patients with lower urinary tract such as overactive bladder and underactive detrusor, including using urine markers and microbiome data, to personalize therapy? ICI‐RS 2023—Part 2

Published:2024-01-04 Issue: Volume: Page:
ISSN:0733-2467
Container-title:Neurourology and Urodynamics
language:en
Short-container-title:Neurourology and Urodynamics

Author:

Finazzi Agrò Enrico¹^ORCID,Rosato Eleonora²^ORCID,Wagg Adrian³,Sinha Sanjay⁴^ORCID,Fede Spicchiale Claudia⁵,Serati Maurizio⁶^ORCID,Mancini Vito⁷^ORCID,de Rijk Mathijs⁸^ORCID,Tarcan Tufan⁹¹⁰^ORCID,Wein Alan¹¹,Abrams Paul¹²^ORCID,Bou Kheir George¹³

Affiliation:

1. Department of Surgical Sciences, University of Rome Tor Vergata and Urology Unit Policlinico Tor Vergata University Hospital Rome Italy

2. School of Specialization in Urology, University of Rome Tor Vergata and Urology Unit Policlinico Tor Vergata University Hospital Rome Italy

3. Department of Medicine University of Alberta Edmonton Alberta Canada

4. Department of Urology Apollo Hospital Hyderabad India

5. Department of Urology, University Hospital Monklands NHS Lanarkshire Airdrie UK

6. Department Obstetrics and Gynecology. Urogynecology Unit University of Insubria Varese Italy

7. Urinary Incontinence Center, Urology and Renal Transplantation Unit Policlinico di Foggia Hospital and University of Foggia Foggia Italy

8. Department of Urology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University Medical Center Maastricht University Maastricht The Netherlands

9. Marmara University School of Medicine Istanbul Turkey

10. Koç University Istanbul Turkey

11. Desai Sethi Institute of Urology, Miller School of Medicine University of Miami Miami Florida USA

12. Department of Urology University of Bristol Bristol UK

13. Gent University Hospital Gent Belgium

Abstract

AbstractIntroductionOveractive bladder (OAB) and underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.ObjectivesThe aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.MethodsA compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU using urodynamic tests, functional neuro‐imaging, urinary markers, and microbiome.Results and ConclusionsThe article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract (LUT) symptoms, such as OAB and UAB. The intricate interplay between the LUT and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one‐size‐fits‐all approach.

Publisher

Wiley

Subject

Urology,Neurology (clinical)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/nau.25379

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