Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process-Reference-Cited by-同舟云学术

Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process

Published:2015-10-15 Issue:6 Volume:31 Page:1657-1668
ISSN:8756-7938
Container-title:Biotechnology Progress
language:en
Short-container-title:Biotechnol Progress

Author:

Zalai Dénes¹²,Koczka Krisztina¹,Párta László¹,Wechselberger Patrick²³,Klein Tobias²³,Herwig Christoph²³

Affiliation:

1. Dept. of Biotechnology; Gedeon Richter Plc.; 19-21, Gyömrői Út Budapest H-1103 Hungary

2. Vienna University of Technology, Institute of Chemical Engineering, Research Area Biochemical Engineering; Vienna Austria

3. CD Laboratory for Mechanistic and Physiological Methods for Improved Bioprocesses; Vienna Austria

Publisher

Wiley

Subject

Biotechnology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/btpr.2179/fullpdf

Reference36 articles.

1. Advanced development strategies for biopharmaceutical cell culture processes;Zalai;Curr Pharm Biotechnol,2015

2. On metabolic shift to lactate consumption in fed-batch culture of mammalian cells;Mulukutla;Metab Eng,2012

3. Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process;Luo;Biotechnol Bioeng,2012

4. Optimizing amino acid composition of CHO cell culture media for a fusion protein production;Xing;Process Biochem,2011

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