Human vaccine candidates for infections caused by Klebsiella pneumoniae: A systematic review

Author:

Motamed Hajar1,Yari Farideh1,Javadirad Etrat2,Golmohammadi Sima3,Alimoradi Saeed4,Naleini Ronak5,Chegene Lorestani Roya6,Nemati Zargaran Fatemeh6,Rostamian Mosayeb67ORCID

Affiliation:

1. Clinical Research Development Center, Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran

2. Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi and Imam Reza Hospitals Kermanshah University of Medical Sciences Kermanshah Iran

3. Department of Internal Medicine, School of Medicine Kermanshah University of Medical Sciences Kermanshah Iran

4. Clinical Research Development Center, Taleghani and Imam Ali Hospital Kermanshah University of Medical Sciences Kermanshah Iran

5. Hematopoietic Stem Cell Research Center Shahid Beheshti University of Medical Sciences Tehran Iran

6. Infectious Diseases Research Center, Health Institute, Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran

7. Student Research Committee Kermanshah University of Medical Sciences Kermanshah Iran

Abstract

AbstractBackground and AimsThere are many difficulties in treating Klebsiella pneumoniae, necessitating the creation of more preventative/therapeutic measures like vaccinations. However, after numerous attempts, there is still no authorized and widely accessible vaccine. The present study aimed to systematically review published studies on K. pneumoniae vaccines in human subjects/samples.MethodsTo find published studies, several electronic databases, including Scopus, PubMed, Web of Science, ClinicalKey, ClinicalTrials.gov, and Cochrane Library were searched without time limitation using the appropriate keywords. Studies were scrutinized, and the information from those that met our inclusion criteria was gathered and analyzed.ResultsIn total, 691 studies were found, of which 14 articles were included for systematic review. Bacterial lysate containing K. pneumoniae was the most studied vaccine candidate. As the main indicator of human immune responses to K. pneumoniae, antibody responses were determined by most studies. The antigen amount, the route of immunization, and the immunization schedule were varying in the studies and were chosen based on several factors such as the disease model, the vaccine type, the vaccination setting (prophylactic or therapeutic), and so on.ConclusionThe majority of studies asserted that their vaccination was efficient and safe, which was demonstrated by a decrease in the rate of infections and the induction of protective antibody, cell‐dependent, and/or cytokine responses. Altogether, the information provided here will help researchers examine the K. pneumoniae vaccine candidates more closely and take future actions that will be more consistently successful.

Funder

Kermanshah University of Medical Sciences

Publisher

Wiley

Reference33 articles.

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