Effects of low‐frequency pulsed electrical stimulation at the common peroneal nerve on chronic refractory wounds of the lower limb: A randomized controlled trial

Author:

Ma Yu12,He Chuan2,Gong Youhui2,Qian Lifang3,Lu Qian2,Li Jinhua3,Zong Li‐Juan4,Song Jie1,Yin Zhifei1ORCID,Shen Ying1ORCID

Affiliation:

1. Rehabilitation Medicine Center The First Affiliated Hospital of Nanjing Medical University Nanjing China

2. Department of Rehabilitation Medicine The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University Suzhou China

3. Oncology Center The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University Suzhou China

4. Department of Rehabilitation Medicine Zhongda Hospital of Southeast University Nanjing China

Abstract

AbstractBackground and aimsElectrical stimulation (ES) has been shown to substantially enhance the quality of life by alleviating pain in patients with chronic wounds. This study aimed to observe the effects of low‐frequency pulsed wearable ES at the common peroneal nerve on chronic refractory wounds of the lower limb.MethodsForty‐eight participants were randomly divided into control group (n = 24) and treatment group (n = 24) in this study. The control group received standard wound care (SWC) exclusively, whereas the treatment group was administered both SWC and the wearable low‐frequency ES targeting the common peroneal nerve. Measurements of wound area, pain intensity, wound status, and quality of life scores were systematically recorded both before and after 4 weeks treatment.ResultsAfter 4 weeks of intervention, the percentage area reduction was significantly higher in the treatment group compared to the control group (Z = −3.9, p < 0.001), and the healing rate of the treatment group was significantly higher than that of the control group (33% vs. 4%). Moreover, the Visual Analog Scale for Pain score (β = −0.65, p = 0.019), the Bates‐Jensen Wound Assessment Tool score (p < 0.05), and the questionnaire on quality of life with chronic wounds (Wound‐Qol) score (β = −4.23, p = 0.003) were significantly decreased in the patients in the treatment group compared to the control group.ConclusionThe wearable low‐frequency pulsed ES at the common peroneal nerve for the treatment of chronic refractory wounds showed significant improvement and were far superior compared to SWC. Future research should broaden its scope to include a diverse range of wound types and benefit from collaboration across multiple research centers.

Publisher

Wiley

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