Pharmacokinetics, Safety, and Tolerability of Single‐Dose Intravenous Moxifloxacin in Pediatric Patients: Dose Optimization in a Phase 1 Study

Author:

Stass Heino1,Lettieri John2,Vanevski Konstantina M.3,Willmann Stefan1,James Laura P.4,Sullivan Janice E.5,Arrieta Antonio C.6,Bradley John S.7

Affiliation:

1. Bayer Wuppertal Germany

2. Bayer Whippany NJ USA

3. Bayer Basel Switzerland

4. Department of PediatricsUniversity of Arkansas for Medical Science and Arkansas Children's Research Institute Little Rock AR USA

5. University of Louisville/Kosair Charities Pediatric Clinical Research Unit/Norton Children's Hospital Louisville KY USA

6. Children's Hospital of Orange County Orange CA USA

7. University of CaliforniaSan Diego School of Medicine and Rady Children's Hospital San Diego San Diego CA USA

Funder

Bayer AG

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference48 articles.

1. Susceptibility ofStreptococcus pneumoniaeto Fluoroquinolones in Canada

2. HackelM BhagwatS KhandeH JoshiP PatelM SahmD.In vitro activity of WCK 771 a new benzoquinolizine quinolone in development against key bacterial groups from the USA and Europe. Presented at the 55th Interscience Conference of Antimicrobial Agents and Chemotherapy in San Diego CA September 17‐21 2015. Poster F‐1196.

3. HawserS HackelM BouchillonS VenteA.Comparative activity of finafloxacin and moxifloxacin against anaerobes. Presented at the 24th European Congress of Clinical Microbiology and Infectious Diseases in Barcelona Spain May 10‐13 2014. Poster E‐113.

4. Moxifloxacin: a review of the microbiological, pharmacological, clinical and safety features

5. Pharmacokinetics and elimination of moxifloxacin after oral and intravenous administration in man

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