Effects of fluoxetine withdrawal in the brainstem and hypothalamus of overnourished rats: Chronic modulation on oxidative stress levels

Author:

de Santana Jonata Henrique1,Rodrigues Thyago de Oliveira1,de Lima Flávia Ariane2,Martins Silva Deyvison Guilherme3,Beltrão de Lemos Maria Daniele Teixeira13,de Andrade Silva Severina Cássia14,Lagranha Cláudia J.134ORCID

Affiliation:

1. Laboratory of Biochemistry and Exercise Biochemistry, Department of Physical Education and Sport Sciences Federal University of Pernambuco – UFPE, Academic Center of Vitória – CAV Vitória de Santo Antão Pernambuco Brazil

2. Graduate Program in Science Teaching Federal Rural University of Pernambuco‐UFRPE Recife Pernambuco Brazil

3. Graduate Program in Biochemistry and Physiology Federal University of Pernambuco‐UFPE Recife Pernambuco Brazil

4. Graduate Program in Neuropsychiatry and Behavioral Sciences Federal University of Pernambuco‐UFPE Recife Pernambuco Brazil

Abstract

AbstractPoor nutritional quality in the early stages of development is associated with neurological diseases in adulthood. Studies showed that obesity‐induced oxidative stress contributes to the genesis of neurological diseases through dysregulation of the brainstem and hypothalamus. Fluoxetine (Fx) is an antidepressant member in the family of selective serotonin reuptake inhibitors (SSRI) that can induce positive effects by reducing oxidative damage in brain tissues. We aimed to evaluate the late effect of Fx in the brainstem and hypothalamus of overnourished rats during development. Male Wistar rats, after birth, were randomly divided into the normal‐nourished group (N, n = 9) and the overnourished group (O, n = 3). On the 39th day of life, the groups were subdivided into normofed, and the overnourished group treated or not with fluoxetine (10 mg/kg daily) (NF, NV, OF, and OV). All groups were treated from the 39th to the 59th day of life, and within 90 days, the tissues were collected for oxidative stress analysis. Briefly, our results showed that Fx treatment induced a tissue‐dependent long‐lasting effect in overfed animals, increasing the enzymatic defense (i.e., CAT and GST activity) in the hypothalamus, but more intensive, increasing the non‐enzymatic defense (i.e., Total Thiols and GSH levels) in the brainstem. Overall, our study suggests that serotonin modulation at the final stage of brain development causes a long‐lasting impact on brain structures in overfed rats at a different mode.

Funder

Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Universidade Federal de Pernambuco

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Wiley

Subject

Developmental Biology,Developmental Neuroscience

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