Utilizing pharmacokinetics/pharmacodynamics modeling to simultaneously examine free CCL2, total CCL2 and carlumab (CNTO 888) concentration time data

Author:

Fetterly Gerald J.1,Aras Urvi1,Meholick Patricia D.1,Takimoto Chris2,Seetharam Shobha2,McIntosh Thomas2,de Bono Johann S.3,Sandhu Shahneen K.3,Tolcher Anthony4,Davis Hugh M.2,Zhou Honghui2,Puchalski Thomas A.2

Affiliation:

1. PK/PD Core Facility, Department of Medicine; Roswell Park Cancer Institute; Buffalo; New York

2. Janssen Research & Development; LLC; Spring House; Pennsylvania

3. Drug Development Unit; Royal Marsden NHS Foundation Trust and The Institute of Cancer Research; Sutton; UK

4. START (South Texas Accelerated Research Therapeutics); San Antonio; Texas

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference25 articles.

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2. The human homolog of the JE gene encodes a monocyte secretory protein;Rollins;Mol Cell Biol.,1989

3. Monocyte chemotactic and activating factor gene expression induced in endothelial cells by IL-1 and tumor necrosis factor;Sica;J Immunol.,1990

4. Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma;Saji;Cancer.,2001

5. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer;Ueno;Clin Cancer Res.,2000

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