Affiliation:
1. Department of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USA
2. Department of Pediatrics Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden
3. Department of Biostatistics St Jude Children's Research Hospital Memphis Tennessee USA
4. Department of Pediatrics Zucker School of Medicine at Hofstra/Northwell New Hyde Park New York USA
5. Department of Pediatrics University of Minnesota Minneapolis Minnesota USA
6. Department of Oncology St Jude Children's Research Hospital Memphis Tennessee USA
Abstract
AbstractBackgroundLifestyle is associated with meningioma risk in the general population.AimsWe assessed longitudinal associations between lifestyle‐associated factors and subsequent meningiomas in childhood cancer survivors.Methods and resultsChildhood cancer survivors age ≥18 years in the St. Jude Lifetime Cohort Study were evaluated for body composition, self‐reported physical activity, cardiopulmonary fitness, muscle strength, smoking, and alcohol consumption at baseline. Time to first meningioma analyses were performed, adjusted for sex, age at diagnosis and baseline assessment, treatment decade, and childhood cancer treatment exposures. The study included 4,072 survivors (47% female; [mean (SD)] 9 (6) years at diagnosis; 30 (8.5) years at the start of follow‐up, with 7.0 (3.3) years of follow‐up). 30% of the participants were survivors of acute lymphoblastic leukemia and 29% of the participants had received cranial radiation. During follow‐up, 90 participants developed ≥1 meningioma, of whom 73% were survivors of acute lymphoblastic leukemia, with cranial radiation being the strongest risk factor (relative risk [RR] 29.7, 95% confidence interval [CI] 10.6‐83.2). Muscle strength assessed by knee extension was associated with a lower risk of developing a meningioma in the adjusted analyses (RR 0.5, 95% CI 0.2‐1.0, p = 0.04 for quartiles 3‐4 vs. 1). No other lifestyle‐associated variable was associated with subsequent meningioma.ConclusionIndependent of cranial radiation, muscle strength was associated with a lower risk of developing a subsequent meningioma in childhood cancer survivors.
Funder
American Lebanese Syrian Associated Charities
Vetenskapsrådet
Svenska Läkaresällskapet
Stiftelsen Blanceflor Boncompagni Ludovisi, född Bildt