1. Department of Internal Medicine Centro Hospitalar de São João EPE Porto Portugal
2. Unidade de Investigaçao Cardiovascular‐UnIC, Faculdade de Medicina Universidade do Porto Porto Portugal
3. Centre d'Investigations Cliniques Plurithématique 1433 and Inserm U1116, CHRU, FCRIN INI‐CRCT (Cardiovascular and Renal Clinical Trialists) Université de Lorraine Nancy France