Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer

Author:

Noonan Anne M.1,Bunch Kristen P.12,Chen Jin-Qiu3,Herrmann Michelle A.3,Lee Jung-Min1,Kohn Elise C.1,O'Sullivan Ciara C.1,Jordan Elizabeth1,Houston Nicole1,Takebe Naoko4,Kinders Robert J.5,Cao Liang6,Peer Cody J.7,Figg W. Douglas7,Annunziata Christina M.1

Affiliation:

1. Women's Malignancies Branch; National Cancer Institute; Bethesda Maryland

2. Department of Gynecologic Oncology; Walter Reed National Military Medical Center; Bethesda Maryland

3. Collaborative Protein Technology Resource; National Cancer Institute; Bethesda Maryland

4. Cancer Therapy Evaluation Program; National Cancer Institute; Shady Grove Maryland

5. Pharmacodynamic Assay Development and Implementation Section, Division of Cancer Treatment and Diagnosis; National Cancer Institute; Frederick Maryland

6. Cancer Genetics Branch; National Cancer Institute; Bethesda Maryland

7. Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research; National Cancer Institute; Bethesda Maryland

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference35 articles.

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2. Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance;Liu;Cancer Res.,2002

3. Altered death receptor signaling promotes epithelial-to-mesenchymal transition and acquired chemoresistance;Antoon;Sci Rep.,2012

4. IAP family proteins-suppressors of apoptosis;Deveraux;Genes Dev.,1999

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