High sensitivity and clonal stability of the genomic fusion as single marker for response monitoring inETV6‐RUNX1‐positive acute lymphoblastic leukemia

Author:

Hoffmann Jana1,Krumbholz Manuela2,Gutiérrez Helia Pimentel1,Fillies Marion1,Szymansky Annabell1,Bleckmann Kirsten3,zur Stadt Udo4,Köhler Rolf5,Kuiper Roland P.6,Horstmann Martin78,Stackelberg Arend1,Eckert Cornelia1ORCID,Metzler Markus2

Affiliation:

1. Pediatric Oncology/HematologyCharité – Universitätsmedizin Berlin Berlin Germany

2. Pediatric Oncology/HematologyUniversity Hospital Erlangen Erlangen Germany

3. Department of PediatricsUniversity of Schleswig‐Holstein Kiel Germany

4. Center for DiagnosticsUniversity Medical Center Hamburg‐Eppendorf Hamburg Germany

5. Institute of Human GeneticsUniversity of Heidelberg Heidelberg Germany

6. Princess Máxima Center for Pediatric Oncology Utrecht The Netherlands

7. Research Institute Children's Cancer Center Hamburg Germany

8. Department of Pediatric Hematology and OncologyUniversity Medical Center Hamburg‐Eppendorf Hamburg Germany

Funder

Deutsche Kinderkrebsstiftung

José Carreras Leukämie-Stiftung

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology, and Child Health

Reference49 articles.

1. Minimal residual disease: optimal methods, timing, and clinical relevance for an individual patient;Schrappe M;Hematology Am Soc Hematol Educ Program,2012

2. Use of Allogeneic Hematopoietic Stem-Cell Transplantation Based on Minimal Residual Disease Response Improves Outcomes for Children With Relapsed Acute Lymphoblastic Leukemia in the Intermediate-Risk Group

3. Relapse in children with acute lymphoblastic leukaemia involving selection of a pre‐existing drug resistant sub‐clone;Choi S;Blood,2007

4. Very early/early relapses of acute lymphoblastic leukemia show unexpected changes of clonal markers and high heterogeneity in response to initial and relapse treatment

5. Assessment of clonal stability of minimal residual disease targets between 1st and 2nd relapse of childhood precursor B‐cell acute lymphoblastic leukemia;Guggemos A;Haematologica,2003

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