Prokineticin‐2 Is Highly Expressed in Colonic Mucosa of Early Parkinson's Disease Patients-Reference-Cited by-同舟云学术

Prokineticin‐2 Is Highly Expressed in Colonic Mucosa of Early Parkinson's Disease Patients

Published:2024-07-25 Issue: Volume: Page:
ISSN:0885-3185
Container-title:Movement Disorders
language:en
Short-container-title:Movement Disorders

Author:

Bellini Gabriele¹²^ORCID,Rettura Francesco³,Palermo Giovanni¹,Ippolito Chiara⁴,Segnani Cristina⁴,Pierucci Clarissa⁴,Fontanelli Lorenzo¹^ORCID,Frosini Daniela⁵,Nardini Vincenzo⁶,Lambiase Christian³,Bernardini Nunzia⁵⁶,Pellegrini Carolina⁴,Ceravolo Roberto¹⁷

Affiliation:

1. Neurology Unit, Department of Clinical and Experimental Medicine University of Pisa Pisa Italy

2. Department of Neurology, the Marlene and Paolo Fresco Institute for Parkinson's Disease and Movement Disorders New York University Langone Health New York New York USA

3. Gastrointestinal Unit, Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Pisa Italy

4. Unit of Histology and Embryology, Department of Clinical and Experimental Medicine University of Pisa Pisa Italy

5. Neurology Unit, Department of Medical Specialties, AOUP Pisa Italy

6. Anatomia Patologica 2 Azienda Ospedaliero‐Universitaria Pisana Pisa Italy

7. Center for Neurodegenerative Diseases, Department of Clinical and Experimental Medicine University of Pisa Pisa Italy

Abstract

AbstractBackgroundElevated levels of prokineticin‐2 (PK2), regarded as a protein involved in modulating immune/inflammatory responses, have been detected in the substantia nigra, serum, and olfactory neurons of Parkinson's disease (PD) patients. Of note, emerging evidence suggests that gut alterations, including dysbiosis and enteric inflammation, play a role in PD via the gut‐brain axis.ObjectivesOur goal was to investigate the expression of PK2 in colonic biopsies of PD patients.MethodsMucosal biopsies from the descending colon were obtained in 11 PD patients and five asymptomatic subjects. Biopsy samples were processed for PK2 immunofluorescence and western blot.ResultsWe revealed an increased PK2 expression in colonic mucosa from PD patients in the early stages compared to controls. In addition, we found that PK2 was expressed by activated enteric glial cells and macrophages.ConclusionsPK2 is highly expressed within neurogenic/inflammatory cells of colonic mucosa from early PD patients, suggesting a potential role of PK2 in gut inflammation, especially in the early stages of PD. © 2024 International Parkinson and Movement Disorder Society.

Publisher

Wiley

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