Autoimmunity, spontaneous tumourigenesis, and IL‐15 insufficiency in mice with a targeted disruption of the tumour suppressor gene Fus1

Author:

Ivanova AV1,Ivanov SV1,Pascal V2,Lumsden JM3,Ward JM4,Morris N5,Tessarolo L6,Anderson SK2,Lerman MI7

Affiliation:

1. Laboratory of Immunobiology, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA

2. Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA

3. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

4. Comparative Medicine Branch, NIAID, & SoBran, Inc., Rockville, MD 20892 USA

5. Laboratory Animal Sciences Program, National Cancer Institute at Frederick, Frederick, MD 21702, USA

6. Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA

7. Basic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference51 articles.

1. The 630‐kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium;Lerman MI;Cancer Res,2000

2. Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells

3. Liposomal vector mediated delivery of the 3p FUS1 gene demonstrates potent antitumor activity against human lung cancer in vivo

4. The Hallmarks of Cancer

5. The Three Es of Cancer Immunoediting

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