Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians-Reference-Cited by-同舟云学术

Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians

Published:2024-01-12 Issue:3 Volume:20 Page:2058-2071
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Ho Pei‐Chuan¹²,Yu Wai Haung³⁴,Tee Boon Lead⁵⁶,Lee Wan‐Ping¹,Li Clara⁷,Gu Yian⁸,Yokoyama Jennifer S.⁵⁹,Reyes‐Dumeyer Dolly¹⁰,Choi Yun‐Beom¹¹¹²,Yang Hyun‐Sik¹³¹⁴¹⁵,Vardarajan Badri N.¹⁰,Tzuang Marian¹⁶,Lieu Kevin⁵,Lu Anna¹⁷,Faber Kelley M.¹⁸,Potter Zoë D.¹⁸,Revta Carolyn¹⁷,Kirsch Maureen¹,McCallum Jake¹⁹,Mei Diana⁵,Booth Briana¹,Cantwell Laura B.¹,Chen Fangcong⁸,Chou Sephera¹⁹,Clark Dewi¹⁹,Deng Michelle¹⁹,Hong Ting Hei²⁰,Hwang Ling‐Jen²¹,Jiang Lilly²⁰,Joo Yoonmee¹⁶,Kang Younhee²²,Kim Ellen S.²³,Kim Hoowon²⁴,Kim Kyungmin²⁵,Kuzma Amanda B.¹,Lam Eleanor¹⁹,Lanata Serggio C.⁵,Lee Kunho²⁶,Li Donghe²⁷,Li Mingyao²⁸,Li Xiang¹⁹,Liu Chia‐Lun¹,Liu Collin²⁹,Liu Linghsi⁷,Lupo Jody‐Lynn¹⁷,Nguyen Khai³⁰,Pfleuger Shannon E.²³,Qian James⁵,Qian Winnie¹⁹,Ramirez Veronica²¹,Russ Kristen A.¹⁸,Seo Eun Hyun³¹,Song Yeunjoo E.³²,Tartaglia Maria Carmela³³,Tian Lu³⁴,Torres Mina³⁵,Vo Namkhue¹⁷,Wong Ellen C.²⁹³⁶,Xie Yuan⁸,Yau Eugene B.²³,Yi Isabelle²¹,Yu Victoria³⁷,Zeng Xiaoyi⁷,St George‐Hyslop Peter³³³⁸,Au Rhoda³⁹⁴⁰,Schellenberg Gerard D.¹,Dage Jeffrey L.¹⁸⁴¹,Varma Rohit³⁵,Hsiung Ging‐Yuek R.²³,Rosen Howard⁵,Henderson Victor W.⁴²⁴³,Foroud Tatiana¹⁸,Kukull Walter A.⁴⁴,Peavy Guerry M.⁴⁵,Lee Haeok⁴⁶,Feldman Howard H.¹⁷⁴⁵,Mayeux Richard⁴⁷,Chui Helena²⁹,Jun Gyungah R.²⁷⁴⁸⁴⁹,Ta Park Van M.¹⁶⁵⁰,Chow Tiffany W.¹⁵¹,Wang Li‐San¹^ORCID

Affiliation:

1. Penn Neurodegeneration Genomics Center Department of Pathology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

2. The Leonard Davis Institute of Health Economics University of Pennsylvania Philadelphia Pennsylvania USA

3. Brain Health and Imaging Center and Geriatric Mental Health Services Centre for Addiction and Mental Health Toronto Ontario Canada

4. Department of Pharmacology and Toxicology University of Toronto Toronto Ontario Canada

5. Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California, San Francisco San Francisco California USA

6. Global Brain Health Institute University of California, San Francisco San Francisco California USA

7. Alzheimer's Disease Research Center Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York USA

8. Department of Neurology Columbia University Medical Center New York New York USA

9. Department of Radiology and Biomedical Imaging University of California, San Francisco San Francisco California USA

10. Gertrude H. Sergievsky Center Taub Institute of Aging Brain and Department of Neurology at Columbia University New York New York USA

11. Englewood Health Englewood New Jersey USA

12. Department of Neurology Rutgers New Jersey Medical School Newark New Jersey USA

13. Center for Alzheimer Research and Treatment Department of Neurology Brigham and Women's Hospital Boston Massachusetts USA

14. Harvard Medical School Boston Massachusetts USA

15. Broad Institute of MIT and Harvard Cambridge Massachusetts USA

16. Department of Community Health Systems University of California San Francisco School of Nursing San Francisco California USA

17. Alzheimer's Disease Cooperative Study University of California, San Diego La Jolla California USA

18. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA

19. Geriatric Mental Health Services, Centre for Addiction and Mental Health Toronto Ontario Canada

20. University of Southern California Los Angeles California USA

21. Stanford Alzheimer's Disease Research Center Stanford California USA

22. College of Nursing Graduate Program in System Health Science and Engineering Ewha Womans University Seoul Republic of Korea

23. Division of Neurology University of British Columbia Vancouver British Columbia Canada

24. Department of Neurology Chosun University Hospital, Dong‐gu Gwangju Republic of Korea

25. Department of Child Development and Family Studies College of Human Ecology Seoul National University Jongno‐gu Seoul Republic of Korea

26. Biomedical Science, College of Natural Sciences Chosun University Gwanak‐gu Seoul Republic of Korea

27. Department of Medicine (Biomedical Genetics) Boston University School of Medicine Boston Massachusetts USA

28. Department of Biostatistics Epidemiology and Informatics Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

29. Department of Neurology Keck School of Medicine at University of Southern California Los Angeles California USA

30. Department of Medicine University of California at San Diego La Jolla California USA

31. Premedical Science, College of Medicine Chosun University, Dong‐gu Gwangju Republic of Korea

32. Department of Population & Quantitative Health Sciences School of Medicine Case Western Reserve University Cleveland Ohio USA

33. Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada

34. Department of Biomedical Data Science Stanford University School of Medicine Stanford California USA

35. Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center Los Angeles California USA

36. Department of Neurology Rancho Los Amigos National Rehabilitation Center Downey California USA

37. Department of Ophthalmology Keck School of Medicine at University of Southern California Los Angeles California USA

38. Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA

39. Department of Anatomy and Neurobiology Slone Epidemiology Center Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA

40. Department of Epidemiology Boston University School of Public Health Boston Massachusetts USA

41. Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA

42. Department of Epidemiology and Population Health Stanford University Stanford California USA

43. Department of Neurology & Neurological Sciences Stanford University Stanford California USA

44. Department of Epidemiology University of Washington Seattle Washington USA

45. Department of Neurosciences University of California San Diego La Jolla California USA

46. Rory Meyers College of Nursing New York University New York New York USA

47. Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University, Vagelos College of Physicians and Surgeons New York New York USA

48. Department of Ophthalmology Boston University School of Medicine Boston Massachusetts USA

49. Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA

50. Asian American Research Center on Health (ARCH) University of California San Francisco School of Nursing San Francisco California USA

51. Alector Inc. South San Francisco California USA

Abstract

AbstractINTRODUCTIONClinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non‐genetic/lifestyle factors impact this multi‐ethnic population.METHODSThe ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese.RESULTSACAD has recruited 606 participants with an additional 900 expressing interest in enrollment since program inception.DISCUSSIONACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. ACAD will recruit > 5000 participants to identify genetic and non‐genetic/lifestyle AD risk factors, establish blood biomarker levels for AD diagnosis, and facilitate clinical trial readiness.HIGHLIGHTS

The Asian Cohort for Alzheimer's Disease (ACAD) promotes awareness of under‐investment in clinical research for Asians.

We are recruiting Asian Americans and Canadians for novel insights into Alzheimer's disease.

We describe culturally appropriate recruitment strategies and data collection protocol.

ACAD addresses challenges of recruitment from heterogeneous Asian subcommunities.

We aim to implement a successful recruitment program that enrolls across three Asian subcommunities.

Funder

National Institute on Aging

National Eye Institute

Korea Brain Research Institute

Alzheimer's Association

Publisher

Wiley

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