Nanomedicine Formulation Using Green Supercritical Processing: Experimental Solubility Measurement and Theoretical Investigation-Reference-Cited by-同舟云学术

Nanomedicine Formulation Using Green Supercritical Processing: Experimental Solubility Measurement and Theoretical Investigation

Published:2023-11-02 Issue:2 Volume:47 Page:318-326
ISSN:0930-7516
Container-title:Chemical Engineering & Technology
language:en
Short-container-title:Chem Eng & Technol

Author:

Arabgol Fatemeh¹,Amani Mitra²³^ORCID,Ardestani Nedasadat Saadati⁴⁵,Sajadian Seyed Ali⁶

Affiliation:

1. Buein Zahra Technical University Department of Chemical and Materials Engineering P.O. Box: 34518-66391 Buein Zahra, Qazvin Iran

2. Islamic Azad University Department of Chemical Engineering, Robat Karim Branch P.O. Box: 37616-16461 Robat Karim Iran

3. Islamic Azad University Department of Chemical Engineering, South Tehran Branch P.O. Box: 15847-43311 Tehran Iran

4. Research Institute of Petroleum Industry (RIPI) Nanotechnology Research Center P.O. Box: 14857-336 Tehran Iran

5. Tarbiat Modares University Department of Chemical Engineering P.O. Box: 14115-111 Tehran Iran

6. University of Kashan Department of Chemical Engineering, Faculty of Engineering P.O. Box: 87317-53153 Kashan Iran

Abstract

AbstractTo develop effective pharmaceutical formulations using supercritical carbon dioxide (scCO2) techniques, it is necessary to obtain the solubility of the medicinal ingredients in scCO2. In the current study, the solubility of Amantadine in scCO2 was evaluated under 28 different operating conditions involving seven pressures and four temperatures. To theoretically study this process, some popular empirical models and two well‐known thermodynamic models (PR‐WS and PC‐SAFT) were examined. The results suggest that the PR‐WS and PC‐SAFT models are the most accurate in establishing a correlation of the solubility of Amantadine in scCO2.

Publisher

Wiley

Subject

Industrial and Manufacturing Engineering,General Chemical Engineering,General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ceat.202300398

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