Affiliation:
1. Shanghai Institute of Technology School of Chemical and Environmental Engineering, Collaborative Innovation Centre of Fragrance Flavor and Cosmetics 201418 Shanghai China
2. Hangzhou Normal University College of Pharmacy 310036 Zhejiang Hangzhou China
Abstract
AbstractSix mathematical models were selected for the fitting and regression of the particle size distribution (PSD) of (α,Z)‐2‐amino‐α‐(methoxyimino)‐4‐thiazole‐ethanethioic acid S‐2‐benzothiazolyl ester (MAEM). The goodness‐of‐fit was evaluated by comparing the evaluation indexes such as R2, Akaike's information criterion (AIC), and root mean square error (RMSE). The top three selected models were further applied and compared for the PSD of MAEM produced under two different stirring speeds with distinct differences in regression coefficients. In addition, FBRM monitored the particle number trends on a lab scale under these stirring speeds. Finally, a feasible reaction mechanism was presented in which the dissolution of reactants was the rate‐controlling step which could explain the significant influence on stirring speed.
Subject
Industrial and Manufacturing Engineering,General Chemical Engineering,General Chemistry