Immune responses to WT1 in patients with AML or MDS after chemotherapy and allogeneic stem cell transplantation

Author:

Casalegno-Garduño Rosaely12,Schmitt Anita2,Spitschak Alf3,Greiner Jochen4,Wang Lei2,Hilgendorf Inken15,Hirt Carsten6,Ho Anthony D.2,Freund Mathias1,Schmitt Michael2

Affiliation:

1. Department of Internal Medicine III; University of Rostock; Rostock Germany

2. Department of Internal Medicine V; University Clinic Heidelberg; Heidelberg Germany

3. Institute of Experimental Gene Therapy and Cancer Research, University of Rostock; Rostock Germany

4. Department of Internal Medicine III; University of Ulm; Ulm Germany

5. Department of Hematology/Oncology; Jena University Hospital; Jena Germany

6. Department of Internal Medicine C; Hematology/Oncology, University of Greifswald; Greifswald Germany

Funder

National Council of Science and Technology (CONACyT), Mexico, Foundation “Deutsche José Carreras Leukämie-Stiftung e.V. (DJCLS),” German Cancer Aid “Deutsche Krebshilfe”

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference45 articles.

1. Cancer vaccines for patients with acute myeloid leukemia-definition of leukemia-associated antigens and current clinical protocols targeting these antigens;Greiner;Haematologica,2006

2. Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression;Oka;Proc Natl Acad Sci USA,2004

3. Complete remission in a patient with recurrent acute myeloid leukemia induced by vaccination with WT1 peptide in the absence of hematological or renal toxicity;Mailander;Leukemia,2004

4. A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS;Keilholz;Blood,2009

5. Clinical peptide vaccination trials for leukemia patients;Casalegno-Garduno;Expert Rev Vaccines,2011

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