Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells-Reference-Cited by-同舟云学术

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Overexpression of transcription factor Foxa1 and target genes remediate therapeutic protein production bottlenecks in Chinese hamster ovary cells

Published:2020-02-23 Issue:4 Volume:117 Page:1101-1116
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotechnology and Bioengineering

Author:

Berger Audrey¹²,Le Fourn Valérie³,Masternak Jacqueline¹,Regamey Alexandre³,Bodenmann Iris³,Girod Pierre‐Alain³,Mermod Nicolas¹^ORCID

Affiliation:

1. Department of Fundamental Microbiology, Institute of Biotechnology University of Lausanne Lausanne Switzerland

2. Present address: Laboratory of Microsystems LMIS4 Ecole Polytechnique Fédérale de Lausanne (EPFL) Lausanne Switzerland

3. Selexis SA Geneva Switzerland

Funder

Kommission für Technologie und Innovation

Université de Lausanne

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27274

Reference52 articles.

1. ERp27, a New Non-catalytic Endoplasmic Reticulum-located Human Protein Disulfide Isomerase Family Member, Interacts with ERp57

2. Cell Engineering for Therapeutic Protein Production

3. ERp57 in neurodegeneration and regeneration

4. An XBP-1 dependent bottle-neck in production of IgG subtype antibodies in chemically defined serum-free Chinese hamster ovary (CHO) fed-batch processes

5. Effect of Increased Expression of Protein Disulfide Isomerase and Heavy Chain Binding Protein on Antibody Secretion in a Recombinant CHO Cell Line

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3. FOXA1 Suppresses Endoplasmic Reticulum Stress, Oxidative Stress, and Neuronal Apoptosis in Parkinson's Disease by Activating PON2 Transcription;Neurotoxicity Research;2024-06-27

4. Synergistic promotion of transient transgene expression in CHO cells by PDI/XBP-1s co-transfection and mild hypothermia;Bioprocess and Biosystems Engineering;2024-02-28

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