INZ‐701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1 ‐Deficient Mice-Reference-Cited by-同舟云学术

INZ‐701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1 ‐Deficient Mice

Published:2021-05-05 Issue:8 Volume:36 Page:1594-1604
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J Bone Miner Res

Author:

Cheng Zhiliang¹^ORCID,O'Brien Kevin¹,Howe Jennifer¹,Sullivan Caitlin¹,Schrier Denis¹,Lynch Angela¹,Jungles Steven¹,Sabbagh Yves¹^ORCID,Thompson David¹

Affiliation:

1. Inozyme Pharma Boston MA USA

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbmr.4315

Reference41 articles.

1. Expression of the murine plasma cell nucleotide pyrophosphohydrolase PC-1 is shared by human liver, bone, and cartilage cells. Regulation of PC-1 expression in osteosarcoma cells by transforming growth factor-beta.

2. Molecular Cloning and Chromosomal Localization of PD-Iβ (PDNP3), a New Member of the Human Phosphodiesterase I Genes

3. Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling

4. Structure of NPP1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification

5. Crystal structures of human ENPP1 in apo and bound forms

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