The Effect of Verapamil, a P-Glycoprotein Inhibitor, on the Pharmacokinetics of Peficitinib, an Orally Administered, Once-Daily JAK Inhibitor-Reference-Cited by-同舟云学术

The Effect of Verapamil, a P-Glycoprotein Inhibitor, on the Pharmacokinetics of Peficitinib, an Orally Administered, Once-Daily JAK Inhibitor

Published:2017-03-16 Issue:6 Volume:6 Page:548-555
ISSN:2160-763X
Container-title:Clinical Pharmacology in Drug Development
language:en
Short-container-title:Clinical Pharmacology in Drug Development

Author:

Zhu Tong¹,Howieson Corrie¹,Wojtkowski Tomasz¹,Garg Jay P.¹,Han David²,Fisniku Ogert³,Keirns James¹

Affiliation:

1. Astellas Pharma Global Development Inc.; Northbrook IL USA

2. California Clinical Trials; PAREXEL International; Glendale CA USA

3. Astellas Research Institute of America LLC; Skokie IL USA

Funder

Astellas Pharma Global Development

Astellas Pharma Inc.

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

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4. A phase 2b, randomized, double-blind, parallel-group, placebo-controlled, dose-finding, multi-center study to evaluate the safety and efficacy of ASP015K in moderate-to-severe rheumatoid arthritis subjects not on concomitant methotrexate;Genovese;Arthritis Rheumatol,2014

5. Peficitinib, a JAK inhibitor, in the treatment of moderate-to-severe rheumatoid arthritis in methotrexate-inadequate responders;Kivitz;Arthritis Rheumatol,2016

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