Icaritin and icariin reduce p‐Tau levels in a cell model of Alzheimer's disease by downregulating glycogen synthase kinase 3β

Author:

Li Ying12,Dai Shirui3,Huang Nanqu1,Wu Jie4,Yu Changyin5,Luo Yong1ORCID

Affiliation:

1. Department of Neurology Third Affiliated Hospital of Zunyi Medical University/First People's Hospital of Zunyi Zunyi Guizhou People's Republic of China

2. Department of Neurology First People's Hospital of Guiyang Guiyang Guizhou People's Republic of China

3. XiangYa School of Medicine Central South University Changsha Hunan People's Republic of China

4. Central Laboratory Third Affiliated Hospital of Zunyi Medical University/First People's Hospital of Zunyi Zunyi Guizhou People's Republic of China

5. Department of Neurology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou People's Republic of China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Process Chemistry and Technology,Drug Discovery,Applied Microbiology and Biotechnology,Biomedical Engineering,Molecular Medicine,General Medicine,Bioengineering,Biotechnology

Reference44 articles.

1. A Hundred Years of Alzheimer's Disease Research

2.

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

3. Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

4. WHO(2014) Facts about ageing. Available from:https://www.who.int/ageing/about/facts/en/.

5. Alzheimer's Disease International. (2016) World Alzheimer Report 2016 Improving healthcare for people living with dementia: Coverage quality and costs now and in the future. Available from:https://www.alz.co.uk/research/world-report-2016.

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