Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells

Author:

Figueroa Bruno,Ailor Eric,Osborne Douglas,Hardwick J. Marie,Reff Mitchell,Betenbaugh Michael J.

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Reference38 articles.

1. Life and death in mammalian cell culture: Strategies for apoptosis inhibition;Arden;Trends Biotechnol,2004

2. Adenovirus E1B 19kDa and bcl-2 proteins interact with a common set of cellular proteins;Boyd;Cell,1994

3. Bik1, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins;Boyd;Oncogene,1995

4. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1;Chau;Mol Cell,2000

5. Bcl-x(L) mediates increased production of humanized monoclonal antibodies in Chinese hamster ovary cells;Chiang;Biotechnol Bioeng,2005

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