Population Pharmacokinetic‐Pharmacodynamic Modeling and Covariate Analyses of Neutropenia and Thrombocytopenia in Patients With Solid Tumors Treated With Lurbinectedin
Author:
Affiliation:
1. Pharma Mar Madrid Spain
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1886
Reference33 articles.
1. PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity
2. Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells
3. Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models
4. FDA Approval Summary: Lurbinectedin for the Treatment of Metastatic Small Cell Lung Cancer
5. First-In-Human Phase I Study of Lurbinectedin (PM01183) in Patients with Advanced Solid Tumors
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1. A Comprehensive Review on the Role of Lurbinectedin in Soft Tissue Sarcomas;Current Treatment Options in Oncology;2024-02
2. A model-based head-to-head comparison of single-agent lurbinectedin in the pivotal ATLANTIS Study;Frontiers in Oncology;2023-06-15
3. Lurbinectedin-induced thrombocytopenia: the role of body surface area;Cancer Chemotherapy and Pharmacology;2022-04-01
4. Integrated exposure–response analysis of efficacy and safety of lurbinectedin to support the dose regimen in small-cell lung cancer;Cancer Chemotherapy and Pharmacology;2021-11-05
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