Plasmonic Nanotags for On‐Dose Authentication of Medical Tablets

Author:

Fukuoka Takao1,Yasunaga Toshiya2,Namura Kyoko1,Suzuki Motofumi1,Yamaguchi Akinobu3ORCID

Affiliation:

1. Department of Micro Engineering Kyoto University Kyoto Daigaku‐Katsura, Nishikyo‐ku Kyoto 615–8540 Japan

2. Laboratory of Pharmaceutical Engineering School of Pharmacy Aichi Gakuin University 1–100 Kushumoto‐cho, Chikusa‐ku, Nagoya Aichi 464–8650 Japan

3. Laboratory of Advanced Science and Technology University of Hyogo 3‐1‐2 Kouto, Kamigori, Ako‐gun Hyogo 678–1205 Japan

Abstract

AbstractPlasmonic nanomaterials have attracted much attention to new anticounterfeiting technology. Since one of current anticounterfeiting problems is fake medical tablets, on‐dose authentication of the tablets is strongly required considering tiny area of tablets, biocompatibility, and long shelf life. Previously, Nanotags consisting of self‐assemblies of colloidal gold nanoparticles with reporter molecules were proposed, which produce characteristic surface enhanced Raman scattering (SERS) activity. However, long‐term stability is rarely discussed for SERS active nanostructures. This study deposits about 10 ng of the Nanotags on a very tiny area of the commercial tablets. Distinguishable SERS signals of reporting molecules are confirmed by 1s irradiation of 785 nm laser over the Nanotags, while Raman spectrum of the ingredients is observed on the tablet without the Nanotags. Rapid authentication of tablets stocked over 8 years is sufficiently carried out. In addition, the Nanotags on the tablets are almost invisible to the eye, in particular, if the tablet surface is uneven or colored. It is considered that the presence of discrete AuNP assemblies allows excellent performances of Nanotag.

Funder

New Energy and Industrial Technology Development Organization

Publisher

Wiley

Subject

Mechanical Engineering,Mechanics of Materials

Reference75 articles.

1. Fighting counterfeiting at the nanoscale

2. OECD Trends in Trade in Counterfeit and Pirated Goods(accessed: March 2019).

3. Office of the United State Trade Representative Releases 2020 Review of Notorious Markets for Counterfeiting and Piracy https://ustr.gov/sites/default/files/files/Press/Releases/2020%20Review%20of%20Gotorious%20Markets%20for%20Counterfeiting%20and%20Piracy%20(final).pdf(accessed: January 2021).

4. INTERPOL. “Global operation sees a rise in fake medical products related to COVID‐19” https://www.interpol.int/News‐and‐Events/News/2020/Global‐operation‐sees‐a‐rise‐in‐fake‐medical‐products‐related‐to‐a‐rise‐in‐fake‐medical‐products‐related‐to‐COVID‐19(accessed: March 2020).

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3