Micelle encapsulation zinc‐doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair-Reference-Cited by-同舟云学术

Micelle encapsulation zinc‐doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair

Published:2023-03-28 Issue:3 Volume:8 Page:
ISSN:2380-6761
Container-title:Bioengineering & Translational Medicine
language:en
Short-container-title:Bioengineering & Transla Med

Author:

Yi Jingyan¹,Luo Xin²,Xing Jinshan³,Gedanken Aharon⁴,Lin Xiukun⁵,Zhang Chunxiang⁶,Qiao Gan²⁷^ORCID

Affiliation:

1. Department of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Nucleic Acid Medicine of Luzhou Key Laboratory, Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan 646000 China

2. Department of Pharmacology, School of Pharmacy, Nucleic Acid Medicine of Luzhou Key Laboratory Southwest Medical University Luzhou Sichuan 646000 China

3. Department of Neurosurgery The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou Sichuan 646000 China

4. Center for Advanced Materials and Nanotechnology Bar‐Ilan University Ramat Gan 52900 Israel

5. College of Marine Sciences Beibu Gulf University 12 Binhai Road Qinzhou 535011 Guangxi China

6. Nucleic Acid Medicine of Luzhou Key Laboratory, Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan 646000 China

7. School of Pharmacy, Central Nervous System Drug Key Laboratory of Sichuan Province, Nucleic Acid Medicine of Luzhou Key Laboratory, Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou 646000 Sichuan China

Abstract

AbstractMicelle Encapsulation Zinc‐doped copper oxide nanocomposites (MEnZn‐CuO NPs) is a novel doped metal nanomaterial prepared by our group based on Zinc doped copper oxide nanocomposites (Zn‐CuO NPs) using non‐micellar beam. Compared with Zn‐CuO NPs, MEnZn‐CuO NPs have uniform nanoproperties and high stability. In this study, we explored the anticancer effects of MEnZn‐CuO NPs on human ovarian cancer cells. In addition to affecting cell proliferation, migration, apoptosis and autophagy, MEnZn‐CuO NPs have a greater potential for clinical application by inducing HR repair defects in ovarian cancer cells in combination with poly (ADP‐ribose) polymerase inhibitors for lethal effects.

Funder

Natural Science Foundation of Sichuan Province

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biotechnology

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