Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?

Author:

Johnson Trevor N.1,Ke Alice B.2

Affiliation:

1. Certara UK Limited Sheffield UK

2. Certara USA, Inc. Princeton New Jersey USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference53 articles.

1. FDA.2018. E11(R1) Addendum: Clinical investigation of medicinal products in the pediatric population.https://www.fda.gov/regulatory-information/search-fda-guidance-documents/e11r1-addendum-clinical-investigation-medicinal-products-pediatric-population. Accessed March 2 2021.

2. EMA.2012. Guideline on pharmaceutical development of medicines for paediatric use.https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-pharmaceutical-development-medicines-paediatric-use_en.pdf. Accessed March 2 2021.

3. Failed pediatric drug development trials;Momper JD;Clin Pharmacol Ther,2015

4. The problems in scaling adult drug doses to children;Johnson TN;Arch Dis Child,2008

5. Recent advances in development and application of physiologically‐based pharmacokinetic (PBPK) models: a transition from academic curiosity to regulatory acceptance;Jamei M;Curr Pharmacol Rep,2016

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