Population pharmacokinetics of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 in healthy volunteers following single and multiple dose regimens

Author:

An Guohua1,Liu Wei1,Katz David A.2,Marek Gerard J.2,Awni Walid1,Dutta Sandeep1

Affiliation:

1. Department of Clinical Pharmacology and Pharmacometrics; R&D, AbbVie Inc.; North Waukegan Road North Chicago IL 60064, USA

2. Neuroscience Clinical Development; R&D, AbbVie Inc.; North Waukegan Road North Chicago IL 60064, USA

Funder

AbbVie

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference32 articles.

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2. Splanchnic cortisol production occurs in humans: evidence for conversion of cortisone to cortisol via the 11-beta hydroxysteroid dehydrogenase (11beta-HSD) type 1 pathway;Basu;Diabetes,2004

3. Minireview: 11beta-hydroxysteroid dehydrogenase type 1 - a tissue-specific amplifier of glucocorticoid action;Seckl;Endocrinology,2001

4. Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues;Ricketts;J Clin Endocrinol Metab,1998

5. Cortisol, 11beta-hydroxysteroid dehydrogenases, and hypertension;Uum;Semin Vasc Med,2004

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