Affiliation:
1. Department of Surgery H. Lee Moffitt Cancer Center and Research Institute University of South Florida Tampa
2. Department of Tumor Biology University of Texas M.D. Anderson Cancer Center Houston
Abstract
Tumor cell metastasis is an extremely complex process governed by many different classes of molecules with each class having a separate function. Metastasis is the result of multiple sequential steps and is a highly organized, nonrandom, and organ‐selective process. Recent advances in tumor and molecular biology have permitted the identification of a variety of heterogeneous molecules governing invasion (degradative enzymes, motility factors), adhesion (integrins, selectins, cadherins, immunoglobulin‐like superfamily, annexins), and growth (paracrine and autocrine growth factors) of tumor cells. This diverse group of biological molecules is collectively responsible for determining whether tumor cells can progress from a single malignant cell to a lethal, multiorgan, metastatic disease.
Cited by
1 articles.
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