Treatment of newly diagnosed severe aplastic anemia in children: Evidence‐based recommendations

Author:

Shimano Kristin A.1ORCID,Rothman Jennifer A.2ORCID,Allen Steven W.3,Castillo Paul4ORCID,de Jong Jill L. O.5,Dror Yigal6ORCID,Geddis Amy E.7,Lau Bonnie W.8ORCID,McGuinn Catherine9,Narla Anupama10,Overholt Kathleen11,Pereda Maria A.12,Sharathkumar Anjali13ORCID,Sasa Ghadir14,Nakano Taizo A.12ORCID,Myers Kasiani15ORCID,Gloude Nicholas J.16,Broglie Larisa17ORCID,Boklan Jessica18

Affiliation:

1. Department of Pediatrics, Division of Allergy, Immunology, and Bone Marrow Transplant University of California San Francisco Benioff Children's Hospital San Francisco California USA

2. Department of Pediatrics, Division of Pediatric Hematology/Oncology Duke University Medical Center Durham North Carolina USA

3. Department of Pediatrics, Pediatric Hematology/Oncology University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh Pittsburgh Pennsylvania USA

4. Department of Pediatrics, Division of Pediatric Hematology Oncology UF Health Shands Children's Hospital Gainesville Florida USA

5. Department of Pediatrics Section of Hematology/Oncology/Stem Cell Transplantation University of Chicago Chicago Illinois USA

6. Department of Pediatrics, Marrow Failure and Myelodysplasia Program Division of Hematology/Oncology The Hospital for Sick Children Toronto Canada

7. Department of Pediatrics, Cancer and Blood Disorders Center Seattle Children's Hospital Seattle Washington USA

8. Department of Pediatrics Pediatric Hematology‐Oncology, Dartmouth‐Hitchcock Lebanon New Hampshire USA

9. Department of Pediatrics, Division of Pediatric Hematology Oncology Weill Cornell Medicine New York New York USA

10. Department of Pediatrics Stanford University School of Medicine Stanford California USA

11. Department of Pediatrics, Pediatric Hematology/Oncology Riley Hospital for Children at Indiana University Indianapolis Indiana USA

12. Department of Pediatrics, Center for Cancer and Blood Disorders Children's Hospital Colorado Aurora Colorado USA

13. Stead Family Department of Pediatrics University of Iowa Carver College of Medicine Iowa City Iowa USA

14. Sarah Cannon Transplant and Cellular Therapy Network San Antonio Texas USA

15. Department of Pediatrics University of Cincinnati College of Medicine, Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center Cincinnati Ohio USA

16. Department of Pediatrics University of California San Diego, Rady Children's Hospital San Diego California USA

17. Department of Pediatric Hematology/Oncology/Blood and Marrow Transplantation Medical College of Wisconsin Milwaukee Wisconsin USA

18. Department of Pediatrics, Center for Cancer and Blood Disorders Phoenix Children's Hospital Phoenix Arizona USA

Abstract

AbstractSevere aplastic anemia (SAA) is a rare potentially fatal hematologic disorder. Although overall outcomes with treatment are excellent, there are variations in management approach, including differences in treatment between adult and pediatric patients. Certain aspects of treatment are under active investigation in clinical trials. Because of the rarity of the disease, some pediatric hematologists may have relatively limited experience with the complex management of SAA. The following recommendations reflect an up‐to‐date evidence‐based approach to the treatment of children with newly diagnosed SAA.

Publisher

Wiley

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