Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia

Author:

Watts Eleanor L.1ORCID,Perez‐Cornago Aurora1ORCID,Fensom Georgina K.1,Smith‐Byrne Karl2,Noor Urwah1,Andrews Colm D.1,Gunter Marc J.3,Holmes Michael V.45,Martin Richard M.678,Tsilidis Konstantinos K.910ORCID,Albanes Demetrius11,Barricarte Aurelio121314,Bueno‐de‐Mesquita Bas15,Chen Chu161718,Cohn Barbara A.19,Dimou Niki L.3ORCID,Ferrucci Luigi20,Flicker Leon2122,Freedman Neal D.11,Giles Graham G.232425,Giovannucci Edward L.262728,Goodman Gary E.16,Haiman Christopher A.29,Hankey Graeme J.21,Huang Jiaqi1130ORCID,Huang Wen‐Yi11ORCID,Hurwitz Lauren M.11ORCID,Kaaks Rudolf31,Knekt Paul32,Kubo Tatsuhiko33,Langseth Hilde934,Laughlin Gail35,Le Marchand Loic36,Luostarinen Tapio37ORCID,MacInnis Robert J.2324,Mäenpää Hanna O.38,Männistö Satu39,Metter E. Jeffrey40,Mikami Kazuya41,Mucci Lorelei A.26,Olsen Anja W.4243,Ozasa Kotaro44,Palli Domenico45ORCID,Penney Kathryn L.2627,Platz Elizabeth A.46ORCID,Rissanen Harri32,Sawada Norie47ORCID,Schenk Jeannette M.48,Stattin Pär49,Tamakoshi Akiko50,Thysell Elin51,Tsai Chiaojung Jillian52,Tsugane Shoichiro47,Vatten Lars53,Weiderpass Elisabete54ORCID,Weinstein Stephanie J.11,Wilkens Lynne R.36,Yeap Bu B.2155,Allen Naomi E.456,Key Timothy J.1,Travis Ruth C.1, , , , ,

Affiliation:

1. Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford Oxford UK

2. Genomic Epidemiology Branch International Agency for Research on Cancer Lyon France

3. Section of Nutrition and Metabolism International Agency for Research on Cancer Lyon France

4. Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health University of Oxford Oxford UK

5. Medical Research Council Population Health Research Unit at the University of Oxford Oxford UK

6. Department of Population Health Sciences, Population Health Sciences, Bristol Medical School University of Bristol Bristol UK

7. MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School University of Bristol Bristol UK

8. National Institute for Health Research (NIHR) Bristol Biomedical Research Centre University Hospitals Bristol NHS Foundation Trust and Weston NHS Foundation Trust and the University of Bristol Bristol UK

9. Department of Epidemiology and Biostatistics, School of Public Health Imperial College London London UK

10. Department of Hygiene and Epidemiology University of Ioannina School of Medicine Ioannina Greece

11. Division of Cancer Epidemiology and Genetics, National Cancer Institute National Institutes of Health Bethesda Maryland USA

12. Navarra Public Health Institute Pamplona Spain

13. Navarra Institute for Health Research (IdiSNA) Pamplona Spain

14. CIBER Epidemiology and Public Health CIBERESP Madrid Spain

15. Centre for Nutrition, Prevention and Health Services National Institute for Public Health and the Environment (RIVM) The Netherlands

16. Program in Epidemiology, Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington USA

17. Department of Epidemiology, School of Public Health University of Washington Seattle Washington USA

18. Department of Otolaryngology: Head and Neck Surgery, School of Medicine University of Washington Seattle Washington USA

19. Child Health and Development Studies Public Health Institute Berkeley California USA

20. National Institute on Aging Baltimore Maryland USA

21. Medical School University of Western Australia Perth Western Australia Australia

22. Western Australian Centre for Health and Ageing University of Western Australia Perth Western Australia Australia

23. Cancer Epidemiology Division Cancer Council Victoria Melbourne Victoria Australia

24. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne Melbourne Victoria Australia

25. Precision Medicine, School of Clinical Sciences at Monash Health Monash University Melbourne Victoria Australia

26. Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA

27. Channing Division of Network Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA

28. Department of Nutrition Harvard T.H. Chan School of Public Health Boston Massachusetts USA

29. Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine University of Southern California/Norris Comprehensive Cancer Center Los Angeles California USA

30. National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University Changsha Hunan China

31. Division of Cancer Epidemiology German Cancer Research Center (DKFZ) Heidelberg Germany

32. Department of Public Health and Welfare National Institute for Health and Welfare Helsinki Finland

33. Department of Public Health and Health Policy, Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

34. Department of Research Cancer Registry of Norway Oslo Norway

35. Herbert Wertheim School of Public Health and Human Longevity Science University of California San Diego San Diego California USA

36. University of Hawaii Cancer Center Honolulu Hawaii USA

37. Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research Helsinki Finland

38. Department of Oncology Helsinki University Central Hospital Helsinki Finland

39. Department of Public Health and Welfare Finnish Institute for Health and Welfare Helsinki Finland

40. Department of Neurology The University of Tennessee Health Science Center, College of Medicine Memphis Tennessee USA

41. Departmemt of Urology Japanese Red Cross Kyoto Daiichi Hospital Kyoto Japan

42. Department of Public Health Aarhus University Aarhus Denmark

43. Danish Cancer Society Research Center Copenhagen Denmark

44. Departmemt of Epidemiology Radiation Effects Research Foundation Hiroshima Japan

45. Cancer Risk Factors and Life‐Style Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network – ISPRO Florence Italy

46. Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA

47. Epidemiology and Prevention Group, Center for Public Health Sciences National Cancer Center Tokyo Japan

48. Cancer Prevention Program, Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle Washington USA

49. Department of Surgical Sciences Uppsala University Uppsala Sweden

50. Hokkaido University Faculty of Medicine Sapporo Japan

51. Department of Medical Biosciences Umeå University Umeå Sweden

52. Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York New York USA

53. Department of Public Health and Nursing, Faculty of Medicine Norwegian University of Science and Technology Trondheim Norway

54. Director Office, International Agency for Research on Cancer World Health Organization Lyon France

55. Department of Endocrinology and Diabetes Fiona Stanley Hospital Perth Western Australia Australia

56. UK Biobank Ltd Stockport UK

Funder

Cancer Research UK

National Cancer Institute

National Institutes of Health

World Cancer Research Fund

Publisher

Wiley

Subject

Cancer Research,Oncology

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