Affiliation:
1. Department of Medicine Division of Gastroenterology Shiga University of Medical Science Shiga Japan
2. Department of General Medicine Shiga University of Medical Science Shiga Japan
3. Department of Radiology Shiga University of Medical Science Shiga Japan
4. Department of Endoscopy Shiga University of Medical Science Shiga Japan
Abstract
AbstractBackground and AimEndoscopic ultrasound shear wave elastography (EUS‐SWE) can facilitate an objective evaluation of pancreatic fibrosis. Although it is primarily applied in evaluating chronic pancreatitis, its efficacy in assessing early chronic pancreatitis (ECP) remains underinvestigated. This study evaluated the diagnostic accuracy of EUS‐SWE for assessing ECP diagnosed using the Japanese diagnostic criteria 2019.MethodsIn total, 657 patients underwent EUS‐SWE. Propensity score matching was used, and the participants were classified into the ECP and normal groups. ECP was diagnosed using the Japanese diagnostic criteria 2019. Pancreatic stiffness was assessed based on velocity (Vs) on EUS‐SWE, and the optimal Vs cutoff value for ECP diagnosis was determined. A practical shear wave Vs value of ≥50% was considered significant.ResultsEach group included 22 patients. The ECP group had higher pancreatic stiffness than the normal group (2.31 ± 0.67 m/s vs. 1.59 ± 0.40 m/s, p < 0.001). The Vs cutoff value for the diagnostic accuracy of ECP, as determined using the receiver operating characteristic curve, was 2.24m/s, with an area under the curve of 0.82 (95% confidence interval: 0.69–0.94). A high Vs was strongly correlated with the number of EUS findings (rs = 0.626, p < 0.001). Multiple regression analysis revealed that a history of acute pancreatitis and ≥2 EUS findings were independent predictors of a high Vs.ConclusionsThere is a strong correlation between EUS‐SWE findings and the Japanese diagnostic criteria 2019 for ECP. Hence, EUS‐SWE can be an objective and invaluable diagnostic tool for ECP diagnosis.
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