Efficacy of a Poly-L-Glutamic Acid-Gemcitabine Conjugate in Tumor-Bearing Mice

Author:

Kiew Lik Voon1,Cheong Soon Keng2,Ramli Ernidila3,Sidik Khalifah4,Lim Tuck Meng5,Chung Lip Yong3

Affiliation:

1. Department of Pharmacology; Faculty of Medicine; University of Malaya; 50603; Kuala Lumpur; Malaysia

2. Faculty of Medicine & Health Sciences; University of Tunku Abdul Rahman (UTAR); Bandar Sungai Long; 43000; Selangor; Malaysia

3. Department of Pharmacy; Faculty of Medicine; University of Malaya; 50603; Kuala Lumpur; Malaysia

4. Department of Biomedical Sciences; University of Illinois College of Medicine; Rockford; IL; 61107; USA

5. Department of Chemical Science; Faculty of Science; University of Tunku Abdul Rahman (UTAR); Jalan Universiti; Bandar Barat; 31900; Kampar; Perak; Malaysia

Publisher

Wiley

Subject

Drug Discovery

Reference20 articles.

1. Schedule-dependent antitumour effect of gemcitabine in in vivo model systems;Braakhuis;Semin Oncol,1995

2. Folate-mediated targeting of polymeric conjugates of gemcitabine;Cavallaro;Int J Pharm,2006

3. Lethal host-versus-graft disease and hypereosinophilia in the absence of MHC I-T-cell interactions;Coudert;J Clin Invest,2000

4. Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors;Csoka;Semin Oncol,1995

5. Polymer conjugates. Pharmacokinetic considerations for design and development;Duncan;Clin Pharmacokinet,1994

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