Prebiotics: Ignored player in the fight against cancer

Author:

Mishra Parichita1,Badiyani Vidhi Manish1,Jain Sakshi2,Subramanian Sruti2,Maharaj Sakshee Vinay2,Kumar Ashwini2,Singh Bhisham Narayan1ORCID

Affiliation:

1. Department of Ageing Research, Manipal School of Life Sciences Manipal Academy of Higher Education Manipal Karnataka India

2. Biotechnology and Bioinformatics Area NIIT University Neemrana Rajasthan India

Abstract

AbstractBackgroundPrebiotics is a relatively neglected area in cancer research, despite evidence suggesting that it plays a key role in suppressing tumour growth and improving immune function.Recent FindingsIncluding prebiotics in the diet has been shown to strengthen the immune system and can better slow down or prevent the growth of tumours. It has also been strongly indicated in various scientific studies that prebiotics can contribute to the sustenance of a healthy microbiome, which in turn plays an important role in increasing the effectiveness and reducing the side effects of cancer treatments.ConclusionIn the present review article we highlight the mechanisms by which prebiotics like inulin, fructooligosaccharide (FOS), β‐glucan, pectin, and xylooligosaccharide (XOS) function. Furthermore, the beneficial effect of incorporating prebiotics during cancer therapy to improvise gut health and prevent/reverse the damage caused to patients due to chemotherapy has also been elaborated.

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference68 articles.

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2. Risk factors: Age. National Cancer Institute. n.d. Accessed February 27 2023.https://www.cancer.gov/about-cancer/causes-prevention/risk/age

3. New approaches and procedures for cancer treatment: Current perspectives

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