Affiliation:
1. Department of Head and Neck Radiotherapy Ward 1 Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong China
2. Department of Nursing Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shangdong China
Abstract
AbstractBackgroundThis study aimed to investigate correlations of the severity of radiation‐induced oral mucositis (RIOM) with epidermal growth factor (EGF) and inflammatory cytokines in patients with head and neck cancer (HNC).MethodsLevels of inflammatory cytokines and EGF in saliva of HNC patients were measured. Correlations of inflammatory cytokines and EGF levels with RIOM severity and pain degree, and their diagnostic values on RIOM severity were determined.ResultsElevated IFN‐γ, TNF‐α, IL‐2, and IL‐6 levels, and reduced IL‐4, IL‐10, and EGF levels were found in patients with severe RIOM. IFN‐γ, TNF‐α, IL‐2, and IL‐6 were positively correlated with RIOM severity, while IL‐10, IL‐4, and EGF were negatively correlated with it. All factors were effective in predicting the severity of RIOM.ConclusionIFN‐γ, TNF‐α, IL‐2, and IL‐6 in saliva of patients with HNC are positively correlated with the severity of RIOM, and IL‐4, IL‐10, and EGF were negatively correlated with it.