Genome-wide two-locus interaction analysis identifies multiple epistatic SNP pairs that confer risk of prostate cancer: A cross-population study

Author:

Shen Jiawei12,Li Zhiqiang13,Song Zhijian1,Chen Jianhua1,Shi Yongyong134

Affiliation:

1. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University; Shanghai China

2. Key Laboratory of Computational Biology; Max Planck Independent Research Group on Population Genomics, Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; Shanghai China

3. The Biomedical Sciences Institute of Qingdao University, Qingdao Branch of SJTU Bio-X Institutes; Qingdao 266071 People's Republic of China

4. Department of Psychiatry; The First Teaching Hospital of Xinjiang Medical University; Urumqi People's Republic of China

Funder

973 Program

863 project

National Natural Science Foundation of China

National High Technology Research and Development Program of China

Program of Shanghai Subject Chief Scientist

Shanghai Key Laboratory of Psychotic Disorders (National Program for Support of Top-Notch Young Professionals)

Shanghai Municipal Education Commission and Shanghai Education Development Foundation (“Shu Guang” project)

Shanghai Jiao Tong Univ Liberal Arts and Sciences Cross-Disciplinary Project

China Postdoctoral Science Foundation

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference49 articles.

1. Prostate cancer epidemiology;Grönberg;Lancet,2003

2. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer;Al Olama;Nat Genet,2014

3. The language of gene interaction;Phillips;Genetics,1998

4. A perspective on epistasis: limits of models displaying no main effect. The;Culverhouse;Am J Hum Genet,2002

5. Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage;Xu;Hum Genet,2004

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