Affiliation:
1. Department of Chemical and Biomolecular Engineering University of Delaware Newark Delaware USA
2. Daniel Baugh Institute of Functional Genomics/Computational Biology, Department of Pathology and Genomic Medicine Thomas Jefferson University Philadelphia Pennsylvania USA
Abstract
AbstractThe baroreflex is a multi‐input, multi‐output physiological control system that regulates blood pressure by modulating nerve activity between the brainstem and the heart. Existing computational models of the baroreflex do not explicitly incorporate the intrinsic cardiac nervous system (ICN), which mediates central control of heart function. We developed a computational model of closed‐loop cardiovascular control by integrating a network representation of the ICN within central control reflex circuits. We examined central and local contributions to the control of heart rate, ventricular functions, and respiratory sinus arrhythmia (RSA). Our simulations match the experimentally observed relationship between RSA and lung tidal volume. Our simulations predicted the relative contributions of the sensory and the motor neuron pathways to the experimentally observed changes in the heart rate. Our closed‐loop cardiovascular control model is primed for evaluating bioelectronic interventions to treat heart failure and renormalize cardiovascular physiology.
Funder
National Heart, Lung, and Blood Institute
National Science Foundation
NIH Office of the Director
Subject
General Chemical Engineering,Environmental Engineering,Biotechnology
Cited by
4 articles.
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