Changes in chemical components and hepatoprotective effect of red Panax notoginseng processed by aspartic acid impregnation treatment

Author:

Cui Ying1ORCID,Wu Jianfa1,Zhang Danli1,Li Dan1,Zhang Jing12,Li Wei12,Wang Chongzhi3,Yuan Chunsu3,Liu Zhi12

Affiliation:

1. College of Chinese Medicinal Materials, Jilin Agricultural University Changchun China

2. Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials Changchun China

3. Tang Center for Herbal Medicine Research and The Pritzker School of Medicine University of Chicago Chicago IL USA

Abstract

AbstractBACKGROUNDRed Panax notoginseng (RPN) is one of the major processed products of P. notoginseng (PN), with more effective biological activities. However, the traditional processing method of RPN has some disadvantages, such as low conversion rate of ginsenosides and long processing time.RESULTSIn this work, we developed a green, safe, and efficient approach for RPN processing by aspartic acid impregnation pretreatment. Our results showed that the optimized temperature, steaming time, and concentration of aspartic acid were 120 °C, 1 h, and 3% respectively. The original ginsenosides in PN treated by aspartic acid (Asp‐PN) were completely converted to rare saponins at 120 °C within just 1 h. The concentration of the rare ginsenosides in Asp‐PN was two times higher than that in untreated RPN. In addition, we examined the protective effect of RPN and Asp‐PN on acetaminophen‐induced liver injury in a mouse model. The results showed that Asp‐PN has significantly more potent hepatoprotective action than the RPN. The hepatoprotection of Asp‐PN in acetaminophen‐induced hepatotoxicity may be due to its anti‐oxidative stress, anti‐apoptotic, and anti‐inflammatory activities.CONCLUSIONThese results indicated that aspartic acid impregnation pretreatment may provide an effective method to shorten the steaming time, improve the conversion rate of ginsenosides, and enhance hepatoprotective activity of RPN. © 2024 Society of Chemical Industry.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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