Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats-Reference-Cited by-同舟云学术

Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats

Published:2015-05-22 Issue:8 Volume:30 Page:1457-1467
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J Bone Miner Res

Author:

Nioi Paul¹,Taylor Scott¹,Hu Rong¹,Pacheco Efrain¹,He Yudong D¹,Hamadeh Hisham¹,Paszty Chris²,Pyrah Ian¹,Ominsky Michael S²,Boyce Rogely Waite¹

Affiliation:

1. Department of Comparative Biology and Safety SciencesAmgen Inc.Thousand OaksCAUSA

2. Department of Metabolic DiseasesAmgen Inc.Thousand OaksCAUSA

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbmr.2482

Reference53 articles.

1. Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

2. Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene Product, a Novel Cystine Knot–Containing Protein

3. Sclerostin Is a Novel Secreted Osteoclast-derived Bone Morphogenetic Protein Antagonist with Unique Ligand Specificity

4. Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

5. Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

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