GLPG1205, a GPR84 Modulator: Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects
Author:
Affiliation:
1. Galapagos Biotech Limited Cambridge UK
2. Galapagos Mechelen Belgium
3. Galapagos Romainville France
Publisher
Wiley
Subject
Pharmacology (medical),Pharmaceutical Science
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.955
Reference17 articles.
1. A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors
2. Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor
3. Medium-chain Fatty Acids as Ligands for Orphan G Protein-coupled Receptor GPR84
4. Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor
5. Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction
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1. PET Imaging of Innate Immune Activation Using 11C Radiotracers Targeting GPR84;JACS Au;2023-12-01
2. Pro-phagocytic function and structural basis of GPR84 signaling;Nature Communications;2023-09-14
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4. Effect of GLPG1205, a GPR84 Modulator, on CYP2C9, CYP2C19, and CYP1A2 Enzymes: In Vitro and Phase 1 Studies;Clinical Pharmacology in Drug Development;2021-05-06
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