Affiliation:
1. Department of Cardiology Herlev‐Gentofte University Hospital Copenhagen Denmark
2. Department of Cardiology, Rigshospitalet University of Copenhagen Copenhagen Denmark
3. Department of Epidemiology and Biostatistics, School of Population Health University of Auckland Auckland New Zealand
4. Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
5. Division of Cardiology Duke University School of Medicine Durham NC USA
6. Duke Clinical Research Institute Durham NC USA
7. Department of Oncology Herlev‐Gentofte University Hospital Copenhagen Denmark
Abstract
ABSTRACTAimExpected 1‐year survival is essential to risk stratification of patients with heart failure (HF); however, little is known about the 1‐year prognosis of patients with HF and cancer. Thus, the objective was to investigate the 1‐year prognosis following new‐onset HF stratified by cancer status in patients with breast, gastrointestinal, or lung cancer.Methods and resultsAll Danish patients with new‐onset HF from 2000 to 2018 were included. Cancer status was categorized as history of cancer (no cancer‐related contact within 5 years of HF diagnosis), non‐active cancer (curative intended procedure administered) and active cancer. Standardized 1‐year all‐cause mortality was reported using G‐computation. Age‐stratified 1‐year all‐cause mortality was estimated using the Kaplan–Meier estimator. In total, 193 359 patients with HF were included, 7.3% had either a breast, gastrointestinal, or lung cancer diagnosis. Patients with cancer were older and more comorbid than patients without cancer. Standardized 1‐year all‐cause mortality (95% confidence intervals) was 24.6% (23.0–26.2%), 27.1% (25.5–28.6%), and 29.9% (25.9–34.0%) for history of breast, gastrointestinal and lung cancer, respectively, which was comparable to patients with non‐active cancers. For active breast, gastrointestinal and lung cancer, standardized 1‐year all‐cause mortality was 36.2% (33.8–38.6%), 49.0% (47.2–50.9%), and 61.6% (59.7–63.5%), respectively. One‐year all‐cause mortality increased incrementally with age, except for active lung cancer.ConclusionStandardized 1‐year all‐cause mortality was comparable for patients with history of cancer and non‐active cancer regardless of cancer type, but varied comprehensively for active cancers. Prognostic impact of age was limited for active lung cancer. Thus, granular stratification of cancer is necessary for optimized management of new‐onset HF.
Subject
Cardiology and Cardiovascular Medicine
Cited by
3 articles.
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